Gonda, X: Serotonin Transporter Gene and Personality:

We investigated the association of depression, anxiety and affective temperaments with 5-HTTLPR. People carrying the s allele were more prone to anxiety, depression and more likely to carry affective temperaments incorporating a depressive component. From the aspect of gene-environment interactions, our results show that the presence of dominant affective temperaments and neuroticism- related traits confers increased vulnerability to chronic stress which plays a crucial role in the development of depression. Our findings open the potential to i ...