Chaston, T: Cytotoxic Mechanisms of Iron Chelators withThera

For many years iron chelators have been used for the treatment of iron overload disease and cancer. Nonetheless, the development of novel synthetic chelators with improved bioavaliability and reduced cytotoxicity remains an area of much interest. This thesis is an examination of some mechanisms through which iron binding agents cause toxicity. Two novel classes of iron chelator were compared to clinically relevant chelators with a range of cytotoxic profiles. A variety of assays were employed to categorise these agents in terms of their capacit ...